Disturbed phospholipid homeostasis in endoplasmic reticulum initiates tri-o-cresyl phosphate-induced delayed neurotoxicity

Disturbed phospholipid homeostasis in endoplasmic reticulum initiates tri-o-cresyl phosphate-induced delayed neurotoxicity

Tri-o-cresyl phosphate (TOCP) is a widely used organophosphorus compound, which can cause a neurodegenerative disorder, i.e., organophosphate-induced delayed neurotoxicity (OPIDN). The biochemical events in the initiation of OPIDN were not fully understood except for the essential inhibition of neuropathy target esterase (NTE). NTE, located in endoplasmic reticulum (ER), catalyzes the deacylati...

Clinical Observation of Acute Delayed Neurotoxicity of Tri Ortho Cresyl Phosphate in Adult Hen

Clinical observation of acute delayed neurotoxicity study for 21 days of organophosphate using triorthocresyl phosphate (TOCP) as a model for organophosphate neurotoxicity, adult hens were dosed by oral gavage with 500mg/kg/bw single dose. Treated hens showed varying degrees of in-coordination, ataxia and paralysis at varying grades and on varying days of treatment mostly depending on the vario...

Interim Specific Ground Water Criterion - Tri-ortho-cresyl phosphate (TOCP)

[A case of tri-ortho-cresyl-phosphate poisoning].

Electron Microscopic Study of Acute Neurotoxicity of Tocp(tri Ortho Cresyl Phosphate) of Sciatic Nerve in Adult Hen

In acute neurotoxicity of TOCP of sciatic nerve there was more neurotic changes as degenerate myelin fibers in comparsm with few changes in the spinal cord. The study was done on 2 groups of adult hen, each group consist of 20 adult hen, 20 untreated control as single dosed orally with corn oil. Treated group of 20 adult hen dosed orally with 500mg/kg TOCP in corn oil as single dose. The experi...